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Current Research Studies: Traumatic Brain Injury (TBI)

In addition to research done through the Traumatic Brain Injury (TBI) Model System of Care, the Department of Rehabilitation Medicine is currently conducting the following TBI studies:


Interpersonal Skills Treatment for TBI Survivors

Treatment for Social Competence in Military Veterans, Service Members and Civilians with Traumatic Brain Injury. This study is a multisite, randomized, controlled trial of a group intervention to improve social competence in survivors of mild and moderate traumatic brain injury (TBI).

This study is no longer seeking volunteers.

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Natural History of Headache Following Mild Traumatic Brain Injury

Researchers at the Department of Rehabilitation Medicine at the University of Washington are conducting a research study to learn more about post traumatic headaches (PTH) after Mild Traumatic Brain Injury (MTBI). Accurate knowledge of the natural history of headache after mild TBI is essential for accurate diagnosis, clinical management, and future investigations of headache intervention in persons with MTBI.

Patients who have been admitted to Harborview Medical Center with a MTBI are recruited for the study and if eligible complete an in person interview within one week of their injury. Subjects will then complete 3 telephone interviews at 3 months, 6 months, and 1 year after their injury. Compensation for completion of the interviews is provided.

For more information please contact the principal investigator, Dr. Jeanne Hoffman.

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Amitriptyline to Prevent Post Traumatic Headache after Mild Traumatic Brain Injury

This study is investigating treatment of post-traumatic headache after mild traumatic brain injury (concussion). Participants will need to have experienced a headache after their recent concussion. There are several parts to this study, which include in person study visits, daily headache questions, and weekly telephone calls.

After completing a baseline interview, participants will be randomly put into one of two groups. Group 1 will begin study medication right away, and Group 2 will wait 30 days to possibly begin medication. The study medication is called, Amitriptyline, and is a FDA approved medication for treating symptoms of depression and for the prevention of migraine headaches.

For more information, or to find out about participating in the study, please see Studies Seeking Volunteers, or contact:
Danielle Lozier, Study Coordinator
206.744.5196
dlozier7@uw.edu [Note that we cannot ensure confidentiality via email]

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Treatment With Sumatriptan for TBI Headache (TWIST)

The TWIST Study will be investigating how people experience their headaches and whether treatment with Sumatriptan (also known by the brand name, Imitrex™) is effective in treating post-traumatic headache pain in people who have had a mild (with adequate documentation), moderate and severe TBI. Since 1991, Sumatriptan has been FDA approved and can be prescribed to treat migraine headache in the general population; so Sumatriptan itself is not new, but using it in the TBI population is new.

The mechanism of post-traumatic headache (PTH) is not well understood. PTH may come in many forms, often including tension-type pain and intermittent migraine-like attacks.  Once post-traumatic headaches occurs, the cycle of ongoing headaches can be more complicated and difficult to treat. However, if treatment is started early, posttraumatic headache may not become a permanent problem. Because we want to see if the medication will work early after injury, enrollment for this study will take place between 3—24  months after brain injury and is for people who are having between 4-15 headaches per month.  Participants in this project will track their headaches using a headache diary (daily questions about activities and headache characteristics).

For more information about participating in the study, please see Studies Seeking Volunteers, or contact:
Leslie Kempthorne, Study Coordinator
206.543.0219
ette@uw.edu [Note that we cannot ensure confidentiality via email]

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Featured Research Articles

Multiple Sclerosis

View the latest research articles on Multiple Sclerosis written by faculty from the Department of Rehabilitation Medicine.

Volunteer to Participate in our Research Studies

The Department of Rehabilitation Medicine is looking for volunteers to participate in research studies on Multiple Sclerosis & Pain Management, and Traumatic Brain Injury.

Featured Faculty

Kathryn Yorkston, PhD

Kathy Yorkston, PhDAs a member of the Department of Rehabilitation Medicine's faculty, Kathryn Yorkston, PhD works in the Neuromuscular Clinic for Speech and Swallowing Disorders, and focuses her research on motor speech disorders in adults. Read more...

View the archive of all Department of Rehabilitation Medicine faculty interviews

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