Skip To Main Content University of Washington Department of Rehabilitation Medicine
  Department of Rehabilitation Medicine 
  maximizing potential across the lifespan


The Meaning of Global Outcome Measures in Pain Clinical Trials: More Than Just Change in Pain Intensity


Jensen MP, Wang W, Potts SL, Gould EM



Publication Info:

Clinical Journal of Pain, :


OBJECTIVES:: To understand the factors that contribute to patient and physician global outcome ratings and the extent to which receiving different doses of opioids or placebo might influence the importance of these factors better. METHODS:: A secondary analysis was performed using data from a prospective, multicenter, double-blind placebo-controlled, and active-controlled parallel group dose-ranging study comparing the efficacy of oxymorphone extended release (ER) 20 mg (ER20, N=121); oxymorphone ER 40 mg (ER40, N=121); oxycodone controlled release 20 mg (Oxy20, N=125); and placebo (N=124) in a sample of patients with osteoarthritis. We performed 2 regression analyses to identify the predictors of pretreatment to posttreatment improvement in patient and physician global ratings of arthritis status. RESULTS:: Improvement in global ratings of arthritis status was strongly associated with a decrease in pain intensity. Pretreatment to posttreatment improvement in physical and psychological functioning made independent contributions to the prediction of both criterion variables. DISCUSSION:: The findings underscore the importance of change in pain intensity as a key correlate of ratings of global improvement. However, pain intensity is not the only important factor. In the current sample, improvement in both physical and psychological functioning made independent contributions to improvements in ratings of osteoarthritis status, supporting global ratings as assessing multicomponent domains. Overall, the findings suggest that when a patient or physician reports that the patient is "doing better," the patient is likely reporting less pain intensity and engaging in more physical activity and feeling better emotionally.

Link to Article:

Featured Research Articles

Chronic Pain

View the latest research articles on Chronic Pain written by faculty from the Department of Rehabilitation Medicine.

Volunteer to Participate in our Research Studies

The Department of Rehabilitation Medicine is looking for volunteers to participate in research studies on Multiple Sclerosis & Pain Management, and Traumatic Brain Injury.

Level A conformance icon, 
          W3C-WAI Web Content Accessibility Guidelines 1.0
Copyright © 2000-2018 University of Washington